Mhinduro yekenza ye endometrial, kubvisa kenza padanho rezvironda zveprecancerous.Kenza yeEndometrial ndeimwe yematatu makuru egomarara mune gynecology.
Gomarara reEndometrial nderimwe regomarara rakaipisisa muhurongwa hwekubereka kwevakadzi, riri pachinzvimbo chechipiri pakati pezvirwere zvechikadzi zvekuzvara muChina, uye rinonyanya kuwanda muvakadzi vemumaguta.Sekureva kwehuwandu kubva kuInternational Agency for Research on Cancer yeWorld Health Organisation, paive nekesi nyowani mazana mana nemakumi maviri ezviuru zvegomarara reendometrial pasi rose muna 2020, nekufa vangangosvika zviuru zana.
Panyaya idzi, vangangosvika zviuru makumi masere nezviviri zvekenza dzegomarara reendometrial dzakataurwa kuChina, nekufa vangangosvika zviuru gumi nezvitanhatu.Zvinofungidzirwa kuti panosvika 2035, kuChina kuchave ne93,000 zviitiko zvitsva zvegomarara reendometrial.
Muyero wekurapa kwekutanga-danho reendometrial cancer wakakwira zvakanyanya, uine makore mashanu ekupona anosvika 95%.Nekudaro, iyo 5-yemakore ekupona kwechikamu IV endometrial cancer ingori 19%.
Gomarara reEndometrial rinonyanya kuwanda muvakadzi vepomenopausal uye perimenopausal, vane avhareji yezera rekutanga makore anosvika makumi mashanu nemashanu.Zvisinei, mumakore achangopfuura, kwave kune kuwedzera kwemaitiro ekuitika kwekenza ye endometrial pakati pevakadzi vane makore makumi mana uye pasi.
Ikozvino hapana nzira yakakodzera yekuongorora cancer endometrial
Kune vakadzi vezera rekubereka, kuongororwa kwekutanga uye kutonga panguva yekenza ye endometrial kunogona kuwedzera kuchengetedza kwekubereka uye kupa mukana wekurarama kwenguva refu.
Nekudaro, parizvino hapana nzira dzakajeka uye dzakaringana dzisiri-invasive dzekuongorora cancer endometrial mukuita kwekiriniki.Zviratidzo zvakadai sekubuda ropa kusingawanzoitiki uye kubuda kwechikadzi mumatanho ekutanga zvinoregeredzwa nyore nyore, zvichiita kuti pave nemukana wakarasika wekukurumidza kuongororwa.
Kuongorora kwekutanga uchishandisa ultrasound imaging uye routine gynecological bvunzo ine yakaderera senitivity.
Kushandiswa kwe hysteroscopy uye pathological biopsy inoparadza, ine anesthesia yakakwirira uye inodhura, uye inogona kukonzera kubuda ropa, utachiona, uye uterine perforation, zvichiita kuti pave nehuwandu hwekurasikirwa kwekuongorora, uye haisi kushandiswa senzira yekuongorora nguva dzose.
Endometrial biopsy sampling inogona kukonzera kusagadzikana, kubuda ropa, kutapukirwa, uye uterine perforation, zvichikonzera kuwanda kwekutadza kuongororwa.
TAGMe DNA Methylation Detection Kits (qPCR) yeEndometrial CancerInotangisa Iyo Era yeEndometrial Cancer Diagnostic uye Kurapa 2.0
TAGMe DNA Methylation Detection Kits (qPCR) yeEndometrial Cancerinogona kunyatso zadzisa kukanganisa kwemaitiro akajairwa ekuvheneka cancer endometrial, kuderedza zvakanyanya kupotsa kuongororwa uye kubatsira varwere kuona masaini egomarara nenguva.
Kuongororwa kwemapofu maviri ndiyo "yegoridhe chiyero" yekusimbisa tekinoroji uye zvakare chiyero chekiriniki icho Epiprobe yagara ichitevedzera!
Mhedzisiro yekuongorora kaviri-mapofu yakaratidza kuti kune cervical scrape samples, iyo AUC yaive 0.86, chaiyo yaive 82.81%, uye senitivity yaive 80.65%;kune uterine cavity brashi samples, iyo AUC yaive 0.83, chaiyo yaive 95.31%, uye sensitivity yaive 61.29%.
Zvezvigadzirwa zvegomarara zvekutanga kuongorora, chinangwa chikuru ndechekuongorora vanhu vangangove nedambudziko pane kuita ongororo chaiyo.
Kune zvigadzirwa zvekutanga kuongororwa kenza, tichifunga kuti chinangwa chekushandiswa kwemushandisi kubvisa njodzi yehurwere uye kudzivirira kuongororwa kwakapotsa zvakanyanya sezvinobvira ndiko kutendeseka kukuru kune vakaedzwa.
The negative predictive value yeTAGMe DNA Methylation Detection Kits (qPCR) yeEndometrial Canceriri 99.4%, zvinoreva kuti muhuwandu hwevanhu vanogamuchira migumisiro yakaipa, 99.4% yemigumisiro yakaipa ndeyechokwadi.Iko kugona kudzivirira kuongororwa kwakarasika kwakakosha, uye ruzhinji rwevashandisi vasina kunaka vanogona kuzorora vaine chokwadi chekuti havafanire kuongororwa nekusaziva nemazinga akanyanya akapotsa kuongororwa.Uku ndiko kudzivirira kukuru kune vashandisi.
Kuzviongorora kwezvipingamupinyi zvekenza ye endometrial.
Nekuvandudzwa kwemararamiro, chiitiko chegomarara reendometrial muChina chave kuwedzera gore negore, uye pane maitiro kune vadiki.
Saka, ndevapi rudzi rwevanhu vanowanzoita kenza ye endometrial?
Kazhinji kutaura, vanhu vane mukana wekuita kenza yeendometrial vane zvinotevera zvitanhatu maitiro:
- Kutambura ne metabolic syndrome: chirwere chinoratidzwa nekufutisa, kunyanya kufutisa mudumbu, pamwe neshuga yepamusoro yeropa, abnormal blood lipids, high blood pressure, nezvimwewo, izvo zvinokanganisa zvakanyanya hutano hwemuviri;
- Kukurudzira kwenguva refu kweesrogen: kuratidzwa kwenguva refu kune imwe chete estrogen stimulation pasina progesterone inoenderana kuchengetedza endometrium;
- Kutanga kwekutanga uye kunonoka kuenda kumwedzi: izvi zvinoreva kuti nhamba yekuenda kumwedzi inowedzera, saka endometrium inoratidzwa kune estrogen kukurudzira kwenguva yakareba;
- Kwete kubereka vana: panguva yekuzvitakura, chiyero cheprogesterone mumuviri chakakwirira, chinogona kuchengetedza endometrium;
- Genetic factor: iyo yakanyanya kirasi ndiyo Lynch syndrome.Kana pane zviitiko zvechidiki zvegomarara remukati, kenza yemudumbu, kana hama dzechikadzi dzine kenza yeovarian, kenza ye endometrial, nezvimwewo pakati pehama dzepedyo, zvinofanirwa kucherechedzwa uye genetic zano uye kuongororwa kunogona kuitwa;
- Hunhu husina hutano hwemararamiro: hwakadai sekuputa, kushaya maekisesaizi, uye kufarira kudya kwakawanda-koriori uye kwakawanda-mafuta senge mbatatisi machipisi, mafrench fries, mukaka tii, chikafu chakakangwa, makeke echokoreti, nezvimwe, saka zvakakosha kurovedza muviri. zvakawanda mushure mekuvapedza.
Unogona kuzvienzanisa nehunhu hutanhatu huri pamusoro hunogona kuita gomarara reendometrial, uye edza kuzvigadzirisa nepaunogona napo kuti uzvidzivirire kubva kunobva.
Nguva yekutumira: Chivabvu-09-2023