TAGMe DNA Methylation Detection Kits (qPCR) yeCervical Cancer / Endometrial Cancer
PRODUCT FEATURES
Non-invasive
Inoshanda necervical brush uye Pap smear samples.
Convenient
Iyo yekutanga Me-qPCR methylation yekuona tekinoroji inogona kupedzwa mudanho rimwe mukati meawa matatu pasina bisulfite shanduko.
Kurumidza
Detectable at the precancerous stage.
Automation
Inoperekedzwa neyakagadzirirwa mhedzisiro yekuongorora software, dudziro yemhedzisiro ndeye otomatiki uye inoverengwa zvakananga.
Maitiro ekushandisa
Kuongororwa kwekutanga
Vanhu vane hutano
Cancer Risk Assessment
Huwandu hwevanhu vane njodzi yakanyanya (yakanaka kune yakanyanya-njodzi yepillomavirus yemunhu (hrHPV) kana yakanaka yecervical exfoliation cytology / yakanaka kune yakanyanya-njodzi yemunhu papillomavirus (hrHPV) kana yakanaka yecervical exfoliation cytology)
Recurrence Monitoring
Prognostic population
ZVIRI KUSHANDISA
Iyi kit inoshandiswa mu in vitro qualitative yekuona hypermethylation yejini PCDHGB7 mune zvienzaniso zvekervical.Kune gomarara remuchibereko, mhedzisiro yakanaka inoratidza njodzi yakawedzera yegiredhi 2 kana yepamusoro-giredhi / yakanyanya advanced cervical intraepithelial neoplasia (CIN2+, kusanganisira CIN2, CIN3, adenocarcinoma in situ, uye kenza yechibereko), izvo zvinoda imwe colposcopy uye / kana histopathological kuongororwa. .Pane zvinopesana, mhinduro dzisina kunaka dzebvunzo dzinoratidza kuti njodzi yeCIN2 + yakaderera, asi njodzi haigone kubviswa zvachose.Kuongororwa kwekupedzisira kunofanirwa kuve kwakavakirwa pacolposcopy uye / kana histopathological mhedzisiro.Uyezve, kune kenza ye endometrial, mhedzisiro yakanaka inoratidza kuwedzera kwengozi ye endometrial precancerous maronda uye kenza, izvo zvinoda imwe histopathological kuongororwa kwe endometrium.Kusiyana neizvi, mhinduro dzisina kunaka dzebvunzo dzinoratidza kuti njodzi ye endometrial precancerous maronda uye kenza yakaderera, asi njodzi haigone kubviswa zvachose.Kuongororwa kwekupedzisira kunofanirwa kuve kwakavakirwa pane histopathological kuongororwa mhedzisiro ye endometrium.
PCDHGB7 inhengo yemhuri yeprotocadherin γ gene cluster.Protocadherin yakawanikwa inodzora zvipenyu zvakaita sekuwedzera kwesero, kutenderera kwesero, apoptosis, kupinda, kutama uye autophagy yemasero ebundu kuburikidza nenzira dzakasiyana-siyana dzekusaina, uye kunyarara kwemajini kunokonzerwa ne hypermethylation yedunhu rinosimudzira zvine hukama zvakanyanya nekuitika uye kusimudzira. kenza dzakawanda.Zvinonzi hypermethylation yePCDHGB7 inosanganiswa nemhando dzakasiyana-siyana dzemamota, akadai seasiri Hodgkin lymphoma, kenza yemazamu, kenza yechibereko, endometrial cancer uye dundira.
ZVINHU ZVINOTAURWA
Iyi kit ine nucleic acid yekubvisa reagent uye PCR yekuona reagent.Nucleic acid inobviswa nemagnetic-bead-based method.Iyi kit yakavakirwa pamusimboti wefluorescence quantitative PCR nzira, uchishandisa methylation-specific real-time PCR reaction yekuongorora template DNA, uye panguva imwe chete kuona CpG nzvimbo dzePCDHGB7 gene uye yemhando yekudzora marker yemukati referensi gene zvidimbu G1 uye G2.Iyo methylation level yePCDHGB7 mumuenzaniso, kana iyo Me value, inoverengerwa maererano nePCDHGB7 gene methylated DNA amplification Ct kukosha uye Ct kukosha kwereferensi.Iyo PCDHGB7 gene hypermethylation yakanaka kana isina kunaka chimiro inotarwa maererano neMe value.
